Genome-wide copy number variation analysis in monozygotic twins
نویسندگان
چکیده
منابع مشابه
LYMPHOID NEOPLASIA Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
1Section of Haemato-Oncology, The Institute of Cancer Research, Surrey, United Kingdom; 2Medical Oncology Unit, Cancer Research UK, London, United Kingdom; 3Academic Unit of Paediatric Oncology, University of Manchester, Teenage Cancer Trust Oncology Unit, Christie Hospital National Health Service Trust, Manchester, United Kingdom; 4University of Tennessee at Chattanooga and T. C. Thompson Chil...
متن کاملEpigenetic Variation in Monozygotic Twins: A Genome-Wide Analysis of DNA Methylation in Buccal Cells
DNA methylation is one of the most extensively studied epigenetic marks in humans. Yet, it is largely unknown what causes variation in DNA methylation between individuals. The comparison of DNA methylation profiles of monozygotic (MZ) twins offers a unique experimental design to examine the extent to which such variation is related to individual-specific environmental influences and stochastic ...
متن کاملMitochondrial DNA Copy Number in Sleep Duration Discordant Monozygotic Twins.
STUDY OBJECTIVES Mitochondrial DNA (mtDNA) copy number is an important component of mitochondrial function and varies with age, disease, and environmental factors. We aimed to determine whether mtDNA copy number varies with habitual differences in sleep duration within pairs of monozygotic twins. SETTING Academic clinical research center. PARTICIPANTS 15 sleep duration discordant monozygoti...
متن کاملCorrigendum: Genome-Wide Analysis of DNA Methylation, Copy Number Variation, and Gene Expression in Monozygotic Twins Discordant for Primary Biliary Cirrhosis
Primary biliary cirrhosis (PBC) is an uncommon autoimmune disease with a homogeneous clinical phenotype that reflects incomplete disease concordance in monozygotic (MZ) twins. We have taken advantage of a unique collection consisting of genomic DNA and mRNA from peripheral blood cells of female MZ twins (n = 3 sets) and sisters of similar age (n = 8 pairs) discordant for disease. We performed a...
متن کاملCopy number variation accuracy in genome-wide association studies.
BACKGROUND/AIM Copy number variations (CNVs) are a major source of alterations among individuals and are a potential risk factor in many diseases. Numerous diseases have been linked to deletions and duplications of these chromosomal segments. Data from genome-wide association studies and other microarrays may be used to identify CNVs by several different computer programs, but the reliability o...
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ژورنال
عنوان ژورنال: Forensic Science International: Genetics Supplement Series
سال: 2017
ISSN: 1875-1768
DOI: 10.1016/j.fsigss.2017.09.075